October 2025: Avraham: Breakthrough in genetic hearing loss research: Mutation identified in Moroccan Jews

A new groundbreaking study, led by Prof. Karen Avraham, Edmond J. Safra member, and her lab members: Research Associated Dr. Zippora Brownstein and PhD student Lara Kamal (Medical & Health Sciences), has identified a previously unknown genetic mutation linked to hereditary deafness in Jews of Moroccan descent.

Published in Human Genomics, the research highlights a mutation in the OTOF gene, currently under advanced gene therapy trials worldwide, making affected individuals potential candidates for future treatment. This discovery marks a significant step toward personalized genetic therapies for hearing loss in Israel.

The study was conducted in collaboration with colleagues from Tel Aviv Sourasky Medical Center, Kaplan Medical Center, Hadassah Medical Center, Rabin Medical Center, the Hebrew University of Jerusalem, and Dor Yeshorim, a nonprofit organization, for prevention of Jewish genetic diseases.

This discovery not only sheds light on the genetic basis of hearing loss in a specific population, but also brings hope to families affected by hereditary deafness. It underscores the importance of combining clinical research, genetic mapping, and international collaboration to advance the future of precision medicine.

The study was featured in online newspapers YNET, ISRAEL SEEN, ISRAELECONOMICO and Sdjewishworld.