May 2021: Madi: a new subtype of B cells common to Malaria, AIDS and Lupus patients
Dr. Asaf Madi, Edmond J. Safra affiliate, and colleagues, identified a new type of atypical B cells in the immune system Malaria, HIV and Lupus patients.
Dr. Asaf Madi, Edmond J. Safra affiliate (Medicine), and colleagues, identified a new type of atypical B cells (ABCs) in the immune system Malaria, HIV and Lupus patients. Using single-cell RNA sequencing, the researchers observed remarkably similar transcriptional profiles for ABCs in the three diseases. The study shows that in a healthy person these cells do not exist, whereas in patients with Malaria, AIDS and Lupus they make up 15-25 percent of the B cells, and do not supply protection from these diseases. The discovery opens a new direction for understanding these diseases.
The study, published in Science Advances, was conducted jointly with colleagues at the National Institutes of Health, USA. One of the students who led this research from Dr. Madi's lab is Ella Goldschmidt, BSc student in Bioinformatics at TAU.
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