January 2025: PNAS journal honors Yosef Shiloh for decades of groundbreaking research on Ataxia-Telangiectasia
A recent PNAS profile highlights Prof. Yosef Shiloh's pivotal research contributions.
Prof. Yosef Shiloh, Edmond J. Safra member (Medicine) and a renowned geneticist, has dedicated his career to unraveling the mysteries of ataxia-telangiectasia (A-T), a rare genetic disorder that causes neurodegeneration, immunodeficiency, and cancer predisposition.
A recent PNAS profile highlights his pivotal contributions, including the 1995 discovery of the ATM gene, which plays a key role in DNA damage response.
Shiloh’s work has expanded our understanding of genome stability, cellular aging, and cancer biology, bridging genetics and precision medicine. Recognized with prestigious awards, including the Israel Prize, he continues to explore A-T’s impact on aging and neurodegeneration. His ongoing research reinforces the power of studying rare diseases to unlock broader medical insights.
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