Distinguished Speaker Series: Distinguished Speaker Series: How did we stop HIV evolution?

Dr. Pleuni Pennings, Department of Biology, San Francisco State University

26 February 2019, 14:00 
Katzir seminar room, Green building, Faculty of Life Sciences, Tel Aviv University 
Distinguished Speaker Series

Abstract:  Drug resistance evolution was a huge problem for HIV treatment from the late 80s all the way until a few years ago. It is often suggested that drug resistance evolution cannot happen when at least three drugs are used at the same time. I will use historical data to show that it is more complicated. The initial three-drug therapies for HIV still allowed for a lot of drug resistance evolution to happen. I will propose a hypothesis that can explain why these early triple-drug therapies still allowed drug resistance evolution to happen and why newer triple-drug therapies work much better – we believe that it is related to spatial structure of drug and virus in the human body. 

 

Host: Dr. Adi Stern, Life Sciences Faculty, TAU.

Tel Aviv University, P.O. Box 39040, Tel Aviv 6997801, Israel
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