Distinguished Speaker Series: Delineating interactions between mutagenic signatures, cellular processes, and environment through computational approaches
Dr. Teresa Przytycka, Head, Algorithmic Methods in Computational and Systems Biology group, NCBI, NLM, NIH Bethesda, MD, USA.
Edmond J. Safra Center for Bioinformatics
Distinguished Speaker Series SEMINAR
Dr. Teresa Przytycka
Head, Algorithmic Methods in Computational and Systems Biology group, NCBI, NLM, NIH Bethesda, MD, USA
"Delineating interactions between mutagenic signatures, cellular processes, and environment through computational approaches "
Thursday, December 8 2022, at 11:00
Check Point building, room 420, TAU
Refreshments from 10:45
Abstract: Cancer genomes accumulate many somatic mutations resulting from carcinogenic exposures, cancer related aberrations of DNA maintenance machinery, and normal stochastic events. These processes often lead to distinctive patterns of mutations, called mutational signatures. However interpreting mutation patterns captured by such signatures is often challenging as specific patterns observed in cancer genomes often emerge as the end effect of interactions between DNA damage, DNA repair, and other molecular processes. Untangling these contributions and identifying interactions between mutagenic and other cellular processes remains difficult. I will discuss computational methods to elucidate the relations between mutational signatures and cellular and environmental processes. In particular, I will discuss computational methods to untangle the contributions of DNA damage and repair processes to mutation signatures and network based approaches to uncover the interactions between mutational signatures and biological processes.
Host: Prof. Roded Sharan, School of Computer Science
