Distinguished Speaker Series: Delineating interactions between mutagenic signatures, cellular processes, and environment through computational approaches

Dr. Teresa Przytycka, Head, Algorithmic Methods in Computational and Systems Biology group, NCBI, NLM, NIH Bethesda, MD, USA.

08 December 2022, 11:00 
Check Point building, room 420, School of Computer Science, TAU. 
Distinguished Speaker Series

Edmond J. Safra Center for Bioinformatics

Distinguished Speaker Series SEMINAR

 

Dr. Teresa Przytycka

Head, Algorithmic Methods in Computational and Systems Biology group, NCBI, NLM, NIH Bethesda, MD, USA

 

"Delineating interactions between mutagenic signatures, cellular processes, and environment through computational approaches "

 

Thursday, December 8 2022, at 11:00

Check Point building, room 420, TAU

Refreshments from 10:45

 

Abstract: Cancer genomes accumulate many somatic mutations resulting from carcinogenic exposures, cancer related aberrations of DNA maintenance machinery, and normal stochastic events.  These processes often lead to distinctive patterns of mutations, called mutational signatures.  However interpreting mutation patterns captured by such signatures is often challenging as specific patterns observed in cancer genomes often emerge as the end effect of  interactions between DNA damage,  DNA repair, and other molecular processes. Untangling these contributions and identifying interactions between mutagenic and other  cellular processes remains difficult. I will discuss computational methods to elucidate the  relations between mutational signatures and cellular and environmental processes. In particular, I will discuss computational methods to untangle the contributions of DNA damage and repair processes to mutation signatures and network based approaches to uncover the interactions between mutational signatures and biological processes.  

 

Host: Prof. Roded Sharan, School of Computer Science

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