A special seminar: Leveraging gene expression imputation techniques for healthcare

A special seminar 

 

 

Speaker: Dr. Assaf Gottlieb, Center for Precision Health, School of Biomedical Informatics, The University of Texas, Health Science Center at Houston

 

 

Title: "Leveraging gene expression imputation techniques for healthcare"

 

 

Time: Thursday June 13 at 11:10 (refreshments from 11:00)

 

 

Place: Schreiber 309, School of Computer Science, TAU

 

 

Abstract: Methods that impute gene expression using genotype data are useful for identifying complex genotype-phenotype associations and as alternatives to genome wide association studies. In my talk, I will discuss two of my recent works that leverage this methodology to 1) bridge population with regard to drug response; and 2) to identify variations in transcription factors that affect transcription.

 

Short bio: Dr. Gottlieb is an Assistant professor at the School of Biomedical Informatics and one of the core faculty members of the Center for Precision Health. He is interested in understanding and modeling drug mode of action and its relation to pharmacogenomics, drug efficacy and adverse reaction. His lab uses an integrative computational approach, combining multiple data types and applying systems medicine, machine learning and causal inference methodologies to identify population and patient-level factors associated with drug efficacy and adverse reactions and to suggest candidates for drug repurposing. Additionally, his research leverages electronic health records for hypothesis generation and validation of therapeutic outcomes.

 

     

Host:  Prof. Roded Sharan, School of Computer Science, TAU