March 2022: Ast: Gene organization within the nucleus

A new study by Prof. Gil Ast, Edmond J. Safra member, shows how genes with different characteristics are arranged in different regions within the nucleus.

March 2022: Ast: Gene organization within the nucleus

 

A new study published in the journal Molecular Cell shows how genes with different characteristics are arranged in different regions within the nucleus. Genes with low guanine and cytosine content (GC) are found in the periphery of the nucleus, and high GC content genes are more concentrated in the center of the nucleus. Moreover, genes in the two regions undergo splicing by different mechanisms.

 

The study, a combination of bioinformatics and biological experiments, was a collaboration of researchers from TAU, Bar-Ilan, Portugal, Spain and USA.

It was led by Prof. Gil Ast, Edmond J. Safra member (Medicine) and his students Luna Tammer and Edmond J. Safra PhD student fellows Ofir Hameiri and Vanessa Roy, and Itay Sason (Sharan lab, Computer Science).

The discovery might contribute to the development of genetic therapies for hereditary diseases and cancer.

 

The article was selected for the cover page of the prestigious journal Molecular Cell, and was featured in the online newspaper N12.

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